منابع مشابه
The Streptokinase-plasminogen System
Human plasminogen, plasma, or serum increased the pathogenicity of six streptokinase-positive streptococcal strains for mice. Combinations of commercial streptokinase and plasminogen or streptokinase and plasma did not usually increase mouse mortality to a greater degree than did plasminogen or plasma alone, suggesting that the maximal effective amount of streptokinase was produced by the organ...
متن کاملPlasminogen Activation With Streptokinase
Background. Platelet activation occurs in vivo during pharmacologic thrombolysis and may contribute to recurrent thrombosis. Plasmin does not directly activate platelets except at high concentrations; thus, the mechanisms for platelet activation during thrombolysis remain undefined. Increases in thrombin activity also occur in patients treated with fibrinolytic agents and may contribute to acti...
متن کاملThe activation of human plasminogen by streptokinase.
Human plasma contains a proteolytic enzyme precursor termed plasminogen (I) or profibrinolysin (2), which, upon activation by physical agents or specific bacterial kinases, is converted to plasmin (1) or fibrinolysin (2). Streptokinase (henceforth referred to as SK), an extracellular hemolytic streptococcal product, has been a commonly used activator for human plasminogen. Two mechanisms have b...
متن کاملInteraction of Streptokinase with Plasminogen
When streptokinase is incubated with human or rabbit plasminogen, one event which occurs is a specific fragmentation of streptokinase. At least five major identifiable streptokinase fragments appear with time, and they possess molecular weights of approximately 40,000 (SK I), 36,000 (SK 2), 31,000 (SK 3), 26,000 (SK 4), and 10,000 (SK 5) under denaturing conditions, as observed on calibrated so...
متن کاملMechanism of activation of human plasminogen by streptokinase. Presence of active center in streptokinase-plasminogen complex.
The role of proactivators for the streptokinase activation of human plasminogen was studied. It was found that plasmin, as well as plasminogen, can form activator complex with streptokinase. The relative importance of these two proactivators for the streptokinase activation of human plasminogen is discussed. The use of the active center-specific reagent, p-nitrophenylp-guanidinobenzoate (NPGB) ...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1959
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.110.2.245